Antibacterial Spectrum of Aspartic Acid Complexes

Background: The study reports the antibacterial spectrum of aspartic acid complexes that with reported antimicrobial activities. Methods: Five antimicrobial complexes of aspartic acid: Cd(asp) , Na[Mn(asp) ], Na [Mn(asp) ],2 3 2 2 Mn(asp) , and Na[Cu(asp) ] were screened for activity against 72 bacterial strains representing aerobic2 3 , and facultative bacteria. The panel of test strains included reference organisms, as well as clinical and environmental isolates from a wide variety of sources. Results: All the agents inhibited all the organisms at 10-20mg/mL with the MIC of 10mg/mL for more that 80% of the test strains. Mn(asp) (MIC = 10mg/mL) was the most active. Cd(asp) [MIC =2 2 10mg/mL for 62/72 (86.11%) and MIC = 20mg/mL for 10/72 (13.9%)] was the least active. S. aureus (MIC = 10mg/mL) was most susceptible while Proteus spp [MIC = 10mg/mL for 11/14 and MIC (20mg/mL) for 3/14 strains] was the least. Best activities were shown against Gram positive bacteria strains. Conclusion: The complexes have broad spectrum of activities against both susceptible and intrinsically resistant strains of bacteria including those known to be opportunistic pathogens. The complexes thus have potential for development as chemotherapeutic agents.