Identification of Key LncRNAs and Pathways in Prediabetes and Type 2 Diabetes Mellitus for Hypertriglyceridemia Patients Based on Weighted Gene Co-Expression Network Analysis

Figures

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  Figure 1. Hierarchical clustering dendrograms of identified co-expressed genes in modules in (A) T2DM versus normal controls, (B) T2DM versus prediabetes and (C) prediabetes versus normal controls (different colors represent different modules).

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  Figure 2. Module preservation analysis. Visualization of the WGCNA network using a heatmap plot in (A) T2DM versus normal controls, (C) T2DM versus prediabetes and (E) prediabetes versus normal controls (The heatmap depicts the topological overlap matrix (TOM) among all genes included in the analysis). (B, D, F) represented the heatmap plot of the adjacencies of modules in T2DM versus normal controls, T2DM versus prediabetes and prediabetes versus normal controls, respectively.

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  Figure 3. Correlation analysis of the modules and clinical traits in (A) T2DM versus normal controls, (B) T2DM versus prediabetes and (C) prediabetes versus normal controls (Each cell contained the corresponding correlation and P value).

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  Figure 4. Differentially expressed lncRNAs in (A) T2DM versus normal controls, (C) T2DM versus prediabetes and (E) prediabetes versus normal controls with volcano plot, and (B, D, F) represented the heatmap plot for above groups, respectively.

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  Figure 5. KEGG pathway analyses of important lncRNAs (intersection of all genes in selected module and differentially expressed lncRNAs) in (A) T2DM versus normal controls, (B) T2DM versus prediabetes and (C) prediabetes versus normal controls.

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  Figure 6. (A) represented relative expression of lncRNAs for ENST00000503273 between T2DM and normal controls. (B, C) represented relative expression of lncRNAs for ENST00000462720 and ENST00000480633 between T2DM and prediabetes, respectively.

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  Figure 7. (A) showed ROC curve for ENST00000503273 between T2DM and normal controls. (B, C) showed ROC curve for ENST00000462720 and ENST00000480633 between T2DM and prediabetes, respectively.