Long non‐coding RNA NEAT1 overexpression associates with increased exacerbation risk, severity, and inflammation, as well as decreased lung function through the interaction with microRNA‐124 in asthma

Figures

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  Figure 1. LncRNA NEAT1 relative expression in asthma. The comparison of lncRNA NEAT1 relative expression among HCs, patients with asthma in remission, and patients with asthma in exacerbation (A). The performance of lncRNA NEAT1 in distinguishing asthma in exacerbation from HCs (B), asthma in exacerbation from asthma in remission (C), and asthma in remission from HCs (D). Comparisons among three groups were conducted by Kruskal‐Wallis test followed by the Dunn's multiple comparisons test. And ROC curves were used to assess the ability of lncRNA NEAT1 in distinguishing HCs, patients with asthma in remission, and patients with asthma in exacerbation. P < .05 was considered significant. LncRNA NEAT1, long non‐coding RNA nuclear‐enriched abundant transcript 1; HCs, healthy controls; ROC, receiver operating characteristic

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  Figure 2. LncRNA NEAT1 relative expression in patients with different exacerbation severity. Correlation of lncRNA NEAT1 relative expression with the asthma exacerbation severity (mild, moderate, severe) was analyzed by Spearman's rank correlation test. P < .05 was considered significant. LncRNA NEAT1, long non‐coding RNA nuclear‐enriched abundant transcript 1

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  Figure 3. Correlation of lncRNA NEAT1 and miR‐124 in asthma. The correlations of lncRNA NEAT1 and miR‐124 in patients with asthma in exacerbation (A), patients with asthma in remission (B), and HCs (C). The comparisons of miR‐124 relative expression among HCs, patients with asthma in remission, and patients with asthma in exacerbation (D). The performances of miR‐124 in distinguishing patients with asthma in exacerbation from HCs (E), patients with asthma in exacerbation from patients with asthma in remission (F), and patients with asthma in remission from HCs (G). The correlations of lncRNA NEAT1 and miR‐124 were conducted by Spearman's rank correlation test. Comparisons among three groups were conducted by Kruskal‐Wallis test followed by the Dunn's multiple comparisons test. And ROC curves were used to assess the ability of miR‐124 in distinguishing HCs, patients with asthma in remission, and patients with asthma in exacerbation. P < .05 was considered significant. LncRNA NEAT1, long non‐coding RNA nuclear‐enriched abundant transcript 1; miR‐124, microRNA‐124; HCs, healthy controls; ROC, receiver operating characteristic