Key result
Sickle cell disease is linked to elevated Ang-1, Ang-2, VEGF, and vWf versus normal controls.
Why the study?
Plasma levels of angiopoietins, VEGF, their soluble receptors, and von Willebrand factor in sickle cell disease patients with varying retinopathy severity and the effects of laser treatment were not well characterized.
Do plasma levels of angiogenesis markers differ in SCD patients with varying degrees of retinopathy compared to controls, and do they change following panretinal laser photocoagulation?
Design
Observational cohort study
Follow-up
6 months after last PRP session
Authors
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Elevated angiogenic markers in SCD are unrelated to retinopathy severity; leaves open their value as biomarkers pending prospective studies.
Observational (n=79)
Do plasma levels of angiogenesis markers differ in SCD patients with varying degrees of retinopathy compared to controls, and do they change following panretinal laser photocoagulation?
p-value: p=<0.01
SCD patients have elevated plasma angiogenesis markers compared to controls, but these do not correlate with retinopathy severity and show limited changes after laser therapy.
Junette Mohan (2005) conducted an observational in Sickle cell disease and proliferative sickle retinopathy (n=79). Sickle cell disease vs. Normal haemoglobin (AA subjects) was evaluated on Plasma levels of Ang-1, Ang-2, Tie-2, VEGF, sFlt-1, and vWf (p=<0.01). Sickle cell disease was associated with significantly raised plasma levels of Ang-1, Ang-2, VEGF, and vWf compared to normal controls (p<0.01), with no differences among retinopathy subgroups.
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