Key result
Exaggerated exercise SBP response in hypertension is linked to a 50% incidence of LVH.
Why the study?
The relationship among systolic blood pressure during exercise, left ventricular hypertrophy, and plasma norepinephrine concentration in patients with essential hypertension was unclear.
Does an exaggerated systolic blood pressure response to dynamic exercise correlate with left ventricular hypertrophy and sympathetic nervous activity in patients with essential hypertension?
Cross-Sectional (n=40)
No
Does an exaggerated systolic blood pressure response to dynamic exercise correlate with left ventricular hypertrophy and sympathetic nervous activity in patients with essential hypertension?
Absolute Event Rate: 50% vs 0%
p-value: p=<0.05
An exaggerated systolic blood pressure response to dynamic exercise in patients with essential hypertension is strongly associated with the presence of left ventricular hypertrophy, suggesting that exercise blood pressure may be a better marker for end-organ damage than resting blood pressure.
May support risk stratification in hypertension; leaves open prospective validation of exercise BP response as LVH predictor.
To investigate the relationship among systolic blood pressure (SBP) during exercise (EX), left ventricular hypertrophy (LVH) and plasma norepinephrine concentration (NE) in patients with essential hypertension (HT), 20 patients with HT and 20 age- and sex-matched normal subjects were studied using treadmill testing. According to the change in SBP from rest to EX (delta SBP), patients with HT were classified into two groups (group I, n = 12, delta SBP less than 72 mmHg: group II, n = 8, delta SBP greater than or equal to 72 mmHg). There were no significant differences between the two groups with regard to SBP at rest, NE at rest and NE on EX. However, SBP at peak EX, delta SBP and the incidence of LVH were greater in group II than in group I. We conclude that exaggerated SBP response to EX in patients with HT is related to LVH.
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Saitoh et al. (1992) conducted a cross-sectional in Essential hypertension (n=40). Exaggerated systolic blood pressure response to exercise (≥72 mmHg increase) vs. Normal systolic blood pressure response to exercise (<72 mmHg increase) was evaluated on Incidence of left ventricular hypertrophy (LVH) (p=<0.05). An exaggerated systolic blood pressure response to dynamic exercise in patients with essential hypertension was significantly associated with a higher incidence of left ventricular hypertrophy (50% vs 0%, p<0.05).
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