Key result
H1N1 infection in mice identifies chromosome 5 and 19 loci controlling weight loss and survival.
Why the study?
Genetic factors modulating the severity of influenza A infection and the specific host sequence variants influencing disease progression were not fully mapped or understood.
Population
53 BXD-type mouse lines derived from C57BL/6J and DBA/2J strains
Comparison
Genetic loci influencing susceptibility to influenza A virus infection
Design
Preclinical genetic mapping study in inbred mouse strains
Follow-up
13 days
Authors
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Warrants investigation of orthologous human loci; leaves open whether these QTLs predict influenza severity in patients.
Identified specific genetic loci (Qivr5 and Qivr19) that control host susceptibility and resistance to influenza A (H1N1) infection in mice.
Nedelko et al. (2012) studied Influenza H1N1 virus infection. Influenza A virus (PR8, H1N1) infection vs. Different genetic strains (C57BL/6J vs DBA/2J and BXD lines) was evaluated on Body weight loss, survival, and mean time to death. Infection of 53 BXD mouse strains with influenza H1N1 identified significant time-dependent susceptibility loci on chromosomes 5 and 19 that control body weight loss and survival.
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