Key result
Autopsy reveals primary cardiac lymphoma with discordant T-cell immunophenotype and clonal IgH rearrangement.
Why the study?
Primary cardiac lymphoma with a T cell immunophenotype and discordant genotype had not been previously reported in the literature.
Case Report (n=1)
This is the first reported case of a primary cardiac lymphoma presenting with a discordant T cell immunophenotype and B cell genotype.
Raises suspicion for lymphoma in refractory myocarditis-like presentations; leaves open the incidence, biology, and management of T-cell primary cardiac lymphomas.
We report the first case in the world literature of a pri mary cardiac lymphoma with a T cell immunophenotype. The patient was a 20 year old male, suspected of having a viral myocarditis, who died from progressive cardiac de compensation. Postmortem examination revealed a diffuse large cell lymphoma confined to the heart that demonstrated a T cell immunophenotype (CD2, CD3, CD45R0, and CD43 positive). Molecular analysis, however, showed clonal rearrangement of the immunoglobulin heavy chain by Southern blot analysis, but not by PCR. The clinical features of the case are described, and the pathologic features are discussed. Mechanisms are suggested to explain the discordant immunophenotype and genotype. (The J Histotechnol 22:325, 1999)
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Jensen et al. (1999) conducted a case report in Primary cardiac lymphoma (n=1). Postmortem examination of a 20-year-old male revealed a primary cardiac lymphoma with a discordant T cell immunophenotype and clonal rearrangement of the immunoglobulin heavy chain.
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