Key result
Active rumination linked to enhanced low-frequency precuneus power and reduced high gamma hippocampal power.
Why the study?
The neurophysiological basis of rumination, a key process in many psychiatric disorders, remains elusive despite neuroimaging evidence implicating the precuneus and hippocampus.
Cross-Sectional (n=21)
The study provides empirical evidence for the neurophysiological basis of rumination, implicating precuneus-hippocampus coupling across neural oscillation bands.
Premature for clinical translation in cardiovascular patients; leaves open causal validation of precuneus-hippocampus oscillations in rumination.
Rumination is a transdiagnostic psychological process that plays a prominent role in many common psychiatric disorders, albeit its neurophysiological basis remains elusive. Existing neuroimaging studies have highlighted the precuneus and hippocampus as two pivotal brain regions in rumination’s neural underpinnings. Here, we examined the intracranial electroencephalogram (iEEG) recordings from 21 patients with epilepsy during a naturalistic, continuous, active rumination state and measured the low frequency (1–8 Hz) and high gamma (70–150 Hz) band oscillation powers. We observed enhanced low-frequency power in the precuneus and reduced high gamma power in the hippocampus during the rumination condition compared to the control condition. The hippocampal high gamma power reduction was associated with the self-reported reflection tendency. Our findings provided empirical evidence of the neurophysiological underpinnings of rumination and implicated a precuneus-hippocampus coupling across neural oscillation bands during an active rumination state.
No takes yet. Share an insight, caveat, or question.
Chen et al. (2024) conducted a cross-sectional in Epilepsy (n=21). Active rumination state vs. Control condition was evaluated on Low frequency (1-8 Hz) and high gamma (70-150 Hz) band oscillation powers in the precuneus and hippocampus. An active rumination state was associated with enhanced low-frequency power in the precuneus and reduced high gamma power in the hippocampus compared to a control condition.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: