Key result
Mild carbon monoxide poisoning increases plateau deep body temperature by ~0.4° C during exertion.
Why the study?
The effects of mild to moderate carbon monoxide poisoning on thermoregulation during work at a fixed workload were not well understood.
Does mild to moderate CO poisoning alter deep body temperature during physical work?
Does mild to moderate CO poisoning alter deep body temperature during physical work?
Mild to moderate CO poisoning increases deep body temperature during physical work, likely due to altered tissue oxygen tension or blood redistribution.
A mild to moderate CO poisoning, blocking 25 to 33 % of the oxygen binding capacity of the blood, was used to produce a change in maximal oxygen intake (max VO2). Subjects working at the same work load (Vo2= 1.5 1/min) for 1 hour under normal conditions and during CO poisoning showed an increase in plateau level of deep body temperature (Te8) of 0.3–0.5° C. The plateau levels correlated with the relative loads (percentage of max Vo2) of the subjects but not with absolute work load and oxygen uptake. The CO‐poisoning may act 1) directly on the hypothalamic temperature center, the low tissue O2 tensions changing the activity of its neurons, 2) through the low venous O2 tensions on peripheral chemoreceptors in the working muscles or the venous side of the circulation, or 3) the changes in temperature may be a passive reaction to a shift in blood towards the periphery in the CO poisoned state.
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Bodil Nielsen (1971) studied Carbon Monoxide Poisoning. Mild to moderate CO poisoning vs. Normal conditions was evaluated on Plateau level of deep body temperature (increase of 0.3-0.5° C). Mild to moderate carbon monoxide poisoning during 1 hour of work increased the plateau level of deep body temperature by 0.3-0.5° C compared to normal conditions.
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