Key result
Inspiring 4% CO2 during exhaustive work reduces peak blood lactate by ~27% versus compressed air.
Why the study?
The metabolic effects of altered CO2 storage during physical activity in humans have not been well documented.
Does inspiring 4% CO2 alter metabolic responses during progressive exhaustive work in humans?
Population
8 human subjects performing progressive bicycle test
Comparison
Inspiring compressed air vs inspiring 4% CO2 and 21% O2
Design
Repeated measures crossover study
Follow-up
30 min recovery period
Authors
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May blunt peak lactate in exhaustive exercise; leaves open performance effects and requires prospective trials before consideration.
Does inspiring 4% CO2 alter metabolic responses during progressive exhaustive work in humans?
Absolute Event Rate: 6.99% vs 9.59%
p-value: p=<=0.05
Inspiring 4% CO2 during exhaustive exercise significantly depresses blood lactate responses, possibly due to glycolytic inhibition and enhanced fat metabolism.
Graham et al. (1980) studied this question. Inspiring 4% CO2 and 21% O2 vs. Compressed air was evaluated on Peak blood lactate (p=<=0.05). Inspiring 4% CO2 during progressive exhaustive work significantly decreased peak blood lactate from 9.59 to 6.99 mM/L compared to compressed air (p<=0.05).
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