August 27, 2022Experimental Physiology
Impairment in maximal lactate steady state after carbon monoxide inhalation is related to training status
Why the study?
The study investigated whether a lower effective hemoglobin concentration induced by carbon monoxide inhalation reduces peak oxygen uptake and maximal lactate steady state, and whether training status explains individual variation.
Does carbon monoxide inhalation reduce peak oxygen uptake and maximal lactate steady state in healthy young participants?
Population
Healthy young participants (n=20 for ramp incremental tests, n=16 for MLSS trials)
Comparison
Carbon monoxide rebreathe tests vs sham procedures
Design
Randomized crossover trial
Authors
Discussion
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Member takes
Implication
Elevated COHb may reduce MLSS and intensify exercise responses; leaves open effects on fitness testing and training.
Structured PICO
Does carbon monoxide inhalation reduce peak oxygen uptake and maximal lactate steady state in healthy young participants?
P
Population
20 healthy young participants (10 female) for ramp incremental tests, and 16 (8 female) for MLSS trials. Males and females were matched for aerobic fitness.
I
Intervention
Carbon monoxide (CO) inhalation via rebreathe tests
C
Comparator
Sham procedures (SHAM)
O
Outcome
Peak oxygen uptake and maximal lactate steady state (MLSS)surrogate
A reduced oxygen-carrying capacity from carbon monoxide inhalation decreases maximal and submaximal exercise performance, with higher aerobic fitness associated with greater impairments.
Cite This Study
Kontro et al. (2022) studied this question.