November 23, 1989New England Journal of Medicine
Short-Term Effects of Carbon Monoxide Exposure on the Exercise Performance of Subjects with Coronary Artery Disease
Why the study?
Does short-term carbon monoxide exposure exacerbate myocardial ischemia during exercise in men with coronary artery disease?
Population
63 men with documented coronary artery disease
Comparison
Exposure to carbon monoxide for 50 to 70 minutes vs Exposure to room air for 50 to 70 minutes
Design
RCT, The order of exposure was assigned randomly, Double-blind
Follow-up
Short-term
Authors
Discussion
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Member takes
Implication
Short-term CO exposure exacerbates exercise ischemia in CAD; confirms dose-dependent risk and supports avoidance counseling.
Structured PICO
Does short-term carbon monoxide exposure exacerbate myocardial ischemia during exercise in men with coronary artery disease?
P
Population
63 men with documented coronary artery disease
I
Intervention
Exposure to carbon monoxide (117 +/- 4.4 ppm or 253 +/- 6.1 ppm) for 50 to 70 minutes
C
Comparator
Exposure to room air for 50 to 70 minutes
O
Outcome
Length of time to a threshold ischemic ST-segment change (ST end point) during exercisesurrogate
Low-level carbon monoxide exposure significantly exacerbates exercise-induced myocardial ischemia in patients with coronary artery disease in a dose-dependent manner.
Cite This Study
Allred et al. (1989) studied this question.