What question did this study set out to answer?

The aim is to investigate the cardiovascular effects of low-level carbon monoxide exposure on angina pectoris.

Effect of Low-Level Carbon Monoxide Exposure on Onset and Duration of Angina Pectoris

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Randomized trial finds low-level carbon monoxide exposure worsens angina symptoms in adults, suggesting health risks from environmental exposure.

The aim is to investigate the cardiovascular effects of low-level carbon monoxide exposure on angina pectoris.
10 adult men with stable angina pectoris were exposed to 50 ppm or 100 ppm CO for 4 hours over 5 days.
Standard treadmill exercise ECG was recorded post-exposure to assess onset and duration of anginal pain.
Carboxyhemoglobin levels were measured pre- and post-exposure.
Mean carboxyhemoglobin levels increased significantly after CO exposure, reaching 4.5% post-100 ppm.
Exercise duration before pain onset was significantly reduced after both CO levels (P < 0.005).
Duration of pain significantly increased after 100 ppm CO compared to air (P < 0.01), with no change after 50 ppm.

Anderson et al. (1973) studied this question.

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Randomized trial finds low-level carbon monoxide exposure worsens angina symptoms in adults, suggesting health risks from environmental exposure.