Carboxyhemoglobin Caused by Smoking Nonnicotine Cigarettes
Key result
Smoking nonnicotine cigarettes reduces exercise time until angina onset by ~24%.
- n=10
Why the study?
The effects of increased carboxyhemoglobin levels caused by smoking nonnicotine cigarettes on exercise-induced angina were not well characterized.
Does smoking nonnicotine cigarettes reduce exercise time to angina in patients with exercise-induced angina?
Population
10 patients with exercise-induced angina
Comparison
Smoking eight nonnicotine cigarettes vs nonsmoking state
Design
Other study design
Authors
Discussion
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Member takes
Overview
May warrant caution with carbon monoxide exposure in angina patients; leaves open nicotine-independent mechanisms of ischemia.
Structured PICO
Does smoking nonnicotine cigarettes reduce exercise time to angina in patients with exercise-induced angina?
P
Population
10 patients with exercise-induced angina.
I
Intervention
Smoking eight nonnicotine cigarettes, one every 30 minutes
C
Comparator
Nonsmoking state
O
Outcome
Mean exercise time from the onset of exercise until the onset of anginasurrogate
Main Result
Absolute Event Rate: 83.5% vs 109.8%
Smoking nonnicotine cigarettes increases carboxyhemoglobin levels and decreases the time to onset of exercise-induced angina, indicating that carbon monoxide alone impairs myocardial oxygen delivery.
Cite This Study
Aronow et al. (1971) studied Exercise-induced angina (n=10). Smoking nonnicotine cigarettes vs. Nonsmoking state was evaluated on Mean exercise time from the onset of exercise until the onset of angina (seconds). Smoking nonnicotine cigarettes significantly decreased the mean exercise time until the onset of angina from 109.8 to 83.5 seconds.