Key result
Smoking nonnicotine cigarettes reduces exercise time until angina onset by ~24%.
Why the study?
The effects of increased carboxyhemoglobin levels caused by smoking nonnicotine cigarettes on exercise-induced angina were not well characterized.
Does smoking nonnicotine cigarettes reduce exercise time to angina in patients with exercise-induced angina?
Does smoking nonnicotine cigarettes reduce exercise time to angina in patients with exercise-induced angina?
Answers are grounded in this paper and cite their sources.
Smoking nonnicotine cigarettes increases carboxyhemoglobin levels and decreases the time to onset of exercise-induced angina, indicating that carbon monoxide alone impairs myocardial oxygen delivery.
The effects of increased carboxyhemoglobin levels caused by smoking nonnicotine cigarettes upon exercise-induced angina were investigated in 10 patients. The mean carboxyhemoglobin level after smoking eight nonnicotine cigarettes, one every 30 minutes, rose from 1.58 to 7.79%. Smoking significantly decreased the mean exercise time from the onset of exercise until the onset of angina from 109.8 to 83.5 seconds. There was significantly less of an increase in systolic blood pressure, heart rate, and product of systolic blood pressure times heart rate after exercise-induced angina after smoking compared to the nonsmoking state. Smoking nonnicotine cigarettes increased the carboxyhemoglobin level, decreasing the rate of oxygen deliverability to the myocardium, with angina developing sooner, following less cardiac work.
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Aronow et al. (1971) studied Exercise-induced angina (n=10). Smoking nonnicotine cigarettes vs. Nonsmoking state was evaluated on Mean exercise time from the onset of exercise until the onset of angina (seconds). Smoking nonnicotine cigarettes significantly decreased the mean exercise time until the onset of angina from 109.8 to 83.5 seconds.
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