Effect of Smoking Cigarettes on Cardiovascular Hemodynamics

Q: What is the clinical evidence from this study?

Population: Angina pectoris due to proved coronary heart disease (n=10). Intervention: Smoking of high-nicotine cigarettes. Primary outcome: Cardiovascular hemodynamics (arterial pressure, heart rate, left ventricular end-diastolic pressure, stroke index, PO2 levels).

Q: What does this research mean for the field?

Smoking high-nicotine cigarettes significantly increases arterial pressure, heart rate, and left ventricular end-diastolic pressure while decreasing stroke index and PO2 levels in patients with coronary heart disease. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Wilbert S. Aronow; John R. Goldsmith; John C. Kern; John Cassidy; John Cassidy; William H. Nelson; Lucien L. Johnson; W. Stirk Adams

doi:10.1080/00039896.1974.10666502

June 1, 1974Archives of Environmental Health An International Journal

Effect of Smoking Cigarettes on Cardiovascular Hemodynamics

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Key result

Smoking high-nicotine cigarettes elevates arterial pressure, heart rate, and LVEDP in angina patients.

n=10

Why the study?

Does smoking high-nicotine cigarettes alter cardiovascular hemodynamics in patients with angina pectoris and coronary heart disease?

Key Points

To assess how smoking high-nicotine cigarettes alters cardiovascular hemodynamics and myocardial oxygen balance in patients with coronary heart disease.
Measured hemodynamic parameters, cardiac pressures, and blood oxygen levels before and after high-nicotine cigarette smoking in ten patients (N=10) with angina pectoris due to confirmed coronary heart disease.
Smoking significantly increased systolic arterial pressure, diastolic arterial pressure, heart rate, and left ventricular end-diastolic pressure.
Stroke index and oxygen tension (PO2) across coronary sinus, arterial, and venous blood decreased significantly following smoking.
No significant changes were detected in the maximal rate of left ventricular pressure rise, aortic systolic ejection period, or cardiac index.

Structured PICO

Does smoking high-nicotine cigarettes alter cardiovascular hemodynamics in patients with angina pectoris and coronary heart disease?

P

Population

10 patients with angina pectoris due to proved coronary heart disease.

E

Exposure

Smoking of high-nicotine cigarettes

O

Outcome

Changes in cardiovascular hemodynamics (systolic and diastolic arterial pressure, heart rate, left ventricular end-diastolic pressure, stroke index, coronary sinus/arterial/venous PO2 levels, maximal rate of left ventricular pressure rise, aortic systolic ejection period, and cardiac index)surrogate

Smoking high-nicotine cigarettes acutely worsens cardiovascular hemodynamics by simultaneously increasing myocardial oxygen demand and interfering with oxygen delivery in patients with coronary heart disease.

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Implication

High-nicotine smoking may worsen hemodynamics in angina; hypothesis-generating and should not yet change practice.

Abstract

Smoking of high-nicotine cigarettes caused a significant increase in systolic and diastolic arterial pressure, heart rate, and left ventricular end-diastolic pressure and a significant decrease in stroke index and coronary sinus, arterial, and venous PO2 level in ten patients with angina pectoris due to proved coronary heart disease. Smoking of the cigarettes did not cause a significant effect on the maximal rate of left ventricular pressure rise, aortic systolic ejection period, and cardiac index in these patients. The smoke of nicotinized cigarettes increases the myocardial oxygen demand (nicotine effect) and interferes with myocardial oxygen delivery (carboxyhemoglobin effect).

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Cite This Study

Aronow et al. (1974) studied Angina pectoris due to proved coronary heart disease (n=10). Smoking of high-nicotine cigarettes was evaluated on Cardiovascular hemodynamics (arterial pressure, heart rate, left ventricular end-diastolic pressure, stroke index, PO2 levels). Smoking high-nicotine cigarettes significantly increased arterial pressure, heart rate, and left ventricular end-diastolic pressure, and decreased stroke index and PO2 levels in angina patients.

synapsesocial.com/papers/6aa4cad2c19a1092ac811d79 https://doi.org/10.1080/00039896.1974.10666502

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Effect of Smoking Cigarettes on Cardiovascular Hemodynamics

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Effect of Smoking Cigarettes on Cardiovascular Hemodynamics

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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