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March 1, 1958Circulation

Effect of Smoking on the Cardiovascular System of Man

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Why the study?

Does smoking increase the risk of adverse cardiovascular effects and coronary artery disease in humans?

Population

Humans

Comparison

Smoking or nicotine injection vs Nonsmokers or baseline (before smoking)

Design

Review

Authors

GRGrace M. RothUniversity of California, Irvine Medical CenterRSRichard M. ShickMayo Clinic

Discussion

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Implication

Supports smoking cessation in at-risk patients; leaves open causal confirmation from higher-level evidence.

Structured PICO

Does smoking increase the risk of adverse cardiovascular effects and coronary artery disease in humans?

P
Population
Humans (including normal subjects, offspring of hypertensive parents, offspring of parents with coronary heart disease, and persons with coronary disease)
I
Intervention
Smoking or nicotine injection
C
Comparator
Nonsmokers or baseline (before smoking)
O
Outcome
Cardiovascular effects (including transient vascular responses, thromboangiitis obliterans, and coronary artery disease incidence and mortality)

This review highlights the detrimental effects of smoking on the cardiovascular system, including increased risk of coronary artery disease and thromboangiitis obliterans.

Cite This Study

Roth et al. (1958) studied this question.

synapsesocial.com/papers/6a8ba774b676b7d1a2fb70c5https://doi.org/10.1161/01.cir.17.3.443
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1EFFECT OF CIGARETTE SMOKE ON THE PERIPHERAL VASCULAR SYSTEM1953 · 15 citations
  2. 2Effect of Cigarette-smoking on Blood Flow Through the Hand1951 · 38 citations
  3. 3THE EFFECT OF SMOKING CIGARETS1944 · 88 citations