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March 1, 2006Journal of Cardiovascular Pharmacology

Nicotine Effect on Cardiovascular System and Ion Channels

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Key result

Nicotine exposure appears to induce a combination of free radical production, vascular wall adhesion, and a reduction of fibrinolytic activity in the plasma.

Why the study?

What are the effects of nicotine on the cardiovascular system and ion channels?

Population

Humans, nicotine-exposed animals, and cell cultures

Design

Review

Authors

SHSalma Toma HannaCenter for Personalized Cancer Treatment

Discussion

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Implication

May warrant nicotine avoidance counseling in vascular patients; leaves open ion channel roles for targeted studies.

Structured PICO

What are the effects of nicotine on the cardiovascular system and ion channels?

P
Population
Humans, nicotine-exposed animals, and cell cultures
I
Intervention
Nicotine and cigarette smoke extract exposure
O
Outcome
Effects on resistance arterioles, compliance arteries, smooth muscle cells, and ion channels in the cardiovascular system

Nicotine exposure alters endothelium-dependent reactivity and cardiovascular function through free radical production, vascular wall adhesion, and reduced fibrinolytic activity.

Limitations

  • Varying and inconsistent results in existing studies due to differences in experimental design, species, and dose of exposure
  • Varying and inconsistent results due to differences in experimental design, species, and dose of exposure

Cite This Study

Salma Toma Hanna (2006) conducted a review in Cardiovascular disease. Nicotine was evaluated. Nicotine exposure appears to induce a combination of free radical production, vascular wall adhesion, and a reduction of fibrinolytic activity in the plasma.

synapsesocial.com/papers/6a127230ea48cb855a34dae8https://doi.org/10.1097/01.fjc.0000205984.13395.9e
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of exogenous free radicals on electromechanical function and metabolism in isolated rabbit and guinea pig ventricle. Implications for ischemia and reperfusion injury.1989 · 141 citations
  2. 2The Effect of Cigarette Smoking on Penile Erection1987 · 97 citations
  3. 3Norepinephrine and Acetylcholine Transmitter Mechanisms in Large Cerebral Arteries of the Pig1982 · 72 citations