September 1, 1969Annals of Internal Medicine
The Effect of Low-Nicotine Cigarettes on Angina Pectoris
Key result
Smoking low-nicotine cigarettes shortens exercise time to angina by ~14% versus nonsmoking.
- shortened by an average of 14%
- n=10
Why the study?
Does smoking low-nicotine cigarettes reduce the time to onset of angina pectoris during exercise in patients with exertional angina?
Population
10 subjects with classical exertional angina pectoris and diseased coronary arteries
Comparison
Smoking a low-nicotine filter cigarette for 5… vs Nonsmoking state prior to exercise
Design
Other
Follow-up
Acute (immediate post-smoking exercise period)
Authors
Discussion
Loading...
Member takes
Overview
Supports caution against low-nicotine smoking in CAD patients; leaves open nicotine reduction's net long-term cardiovascular effects.
Structured PICO
Does smoking low-nicotine cigarettes reduce the time to onset of angina pectoris during exercise in patients with exertional angina?
P
Population
10 subjects with classical exertional angina pectoris who underwent exercise testing in both smoking and nonsmoking states.
I
Intervention
Smoking a low-nicotine filter cigarette for 5 minutes prior to exercise
C
Comparator
Nonsmoking state prior to exercise
O
Outcome
Time to onset of angina pectoris during bicycle ergometer exercise (60 w load)surrogate
Main Result
Effect estimate: shortened by an average of 14%
Smoking even low-nicotine cigarettes acutely decreases exercise tolerance and hastens the onset of angina in patients with coronary artery disease by increasing myocardial oxygen demand.
Cite This Study
Wilbert S. Aronow (1969) studied Classical exertional angina pectoris (n=10). Low-nicotine filter cigarette vs. Nonsmoking state was evaluated on Exercise period before onset of angina pectoris (shortened by an average of 14%). Smoking a low-nicotine filter cigarette shortened the exercise period before the onset of angina by an average of 14% compared to a nonsmoking state.