Key result
Inspiring supplemental CO2 during steady-state exercise reduces blood lactate ~43% versus control.
Why the study?
Altering CO2 stores influences intracellular lactate production and tissue lactate release during exercise, but effects during steady-state exercise at different intensities were not fully characterized.
Does inspiring CO2 alter the metabolic response and blood lactate levels during steady-state exercise?
Population
6 subjects performing steady-state exercise at 50% and 65% VO2max
Comparison
Inspiring 0%, 2%, 4%, or 6% CO2 with 21% O2 during exercise
Design
Experimental study with repeated measures on eight occasions
Follow-up
30 minutes
Authors
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Hypercapnia may modulate lactate during submaximal exercise; leaves open performance or clinical applications pending randomized trials.
Does inspiring CO2 alter the metabolic response and blood lactate levels during steady-state exercise?
Absolute Event Rate: 2.22% vs 3.88%
p-value: p=<0.05
Hypercapnia during steady-state exercise reduces blood lactate levels, suggesting an inhibition of carbohydrate metabolism and enhancement of lipid metabolism.
GRAHAM et al. (1982) studied this question. Hypercapnia (inspired CO2) vs. 0% CO2 was evaluated on Blood lactate concentration at 65% VO2max (p=<0.05). Inspiring 6% CO2 during steady-state exercise at 65% VO2max decreased mean blood lactate from 3.88 mM/L to 2.22 mM/L compared to 0% CO2 (P<0.05).
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