Key result
Slow-transit and dyssynergic chronic constipation link to distinct dysbiosis predicted by depression and poor sleep.
Why the study?
Patients with chronic constipation show altered gut microbial composition, but previous studies lacked subtype stratification to clarify differences in microbiota.
Population
53 patients with chronic constipation and 31 healthy individuals
Comparison
Slow-transit constipation vs normal-transit constipation; dyssynergic defecation vs non-dyssynergic defecation
Design
Prospective cohort study
Authors
Loading...
Subtype-specific dysbiosis in chronic constipation may guide future trials; leaves open whether targeting microbiota or mood/sleep improves outcomes.
Cohort (n=84)
Different subtypes of chronic constipation are associated with distinct patterns of gut dysbiosis, which are also influenced by depression and sleep quality.
Yu et al. (2023) conducted a cohort in chronic constipation (n=84). Chronic constipation subtypes vs. Healthy controls and other constipation subtypes was evaluated on Fecal microbiota composition. Patients with slow-transit and dyssynergic defecation chronic constipation subtypes exhibited distinct dysbiosis, with depression and poor sleep acting as main predictors of altered microbiota.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: