Key result
Computational physiological models realistically simulate cardiogenic shock and therapeutic responses for clinical education.
Why the study?
Computational physiological modeling offers potential for in-depth understanding of complex cardiopulmonary pathophysiology during cardiogenic shock treated with tMCS devices.
Computational physiological models enhance the understanding of cardiogenic shock pathophysiology and temporary mechanical circulatory support management, serving as valuable educational tools with potential future clinical applications.
May enhance cardiogenic shock training; leaves open prospective validation for clinical decision support.
PURPOSE OF REVIEW: The purpose of this review is to explain the value of computational physiological modeling for in-depth understanding of the complex derangements of cardiopulmonary pathophysiology during cardiogenic shock, particularly when treated with temporary mechanical circulatory support (tMCS) devices. RECENT FINDINGS: Computational physiological models have evolved in recent years and can provide a high degree of clinical realism in the simulation of cardiogenic shock and related conservative and interventional therapies. These models feature a large spectrum of practically relevant hemodynamic and respiratory parameters tunable to patient-specific disease states as well as adjustable to medical therapies and support device settings. Current applications work in real-time and can operate on an ordinary computer, laptop or mobile device. SUMMARY: The use of computational physiological models is increasingly appreciated for educational purposes as they help to understand the complexity of cardiogenic shock, especially when sophisticated management of tMCS is involved in addition to multimodal critical care support. Practical implementation of computational models as clinical decision support tools at the bedside is at the horizon but awaits rigorous clinical validation.
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Meuwese et al. (2024) conducted a review in Cardiogenic shock. Computational physiological modeling was evaluated. Computational physiological models provide a high degree of clinical realism in simulating cardiogenic shock and related therapies, serving as valuable educational tools.
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