Key result
Loeys-Dietz syndrome is linked to frequent aortic aneurysms and a ~4% dissection rate during pregnancy.
Why the study?
The spectrum of characteristics and complications of Loeys-Dietz syndrome is not fully understood due to the recent discovery of its underlying genetic mutations.
Systematic Review (n=3,896)
Loeys-Dietz syndrome is a multisystem connective tissue disorder with a high burden of cardiovascular complications, notably aortic aneurysms and dissections, requiring a multidisciplinary approach.
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Pregnancy in Loeys-Dietz syndrome warrants aortic surveillance and counseling; extends aggregated evidence for multidisciplinary risk stratification.
Gouda et al. (2022) conducted a systematic review in Loeys-Dietz syndrome (n=3,896). Loeys-Dietz syndrome was evaluated on Clinical features and complications. Loeys-Dietz syndrome is associated with a high burden of complications, most commonly aortic aneurysms and dissections, with a 4% rate of aortic dissection and 1% peripartum mortality in pregnancies.
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