Impact of Percutaneous Coronary Intervention on Prothrombogenic Potential in Patients With Acute Myocardial Infarction and Diabetes Mellitus Type 2

The aim: Aim of study is to assess the influence of urgent reperfusion strategy on the levels of vWf, PAI-1 and sCD40L in patients with acute myocardial infarction (AMI) and concomitant diabetes mellitus type 2 (DM2). Materials and methods: 255 patients with acute myocardial infarction took part in the study, they were divided into four groups depending on the presence of concomitant diabetes mellitus type 2 and performed treatment: I group – 83 diabetic patients who were underwent urgent reperfusion therapy; II group – 60 diabetic patients who received standard anticoagulant therapy; III group – 65 non-diabetic patients who were underwent urgent reperfusion therapy; IV group – 47 non-diabetic patients who received standard anticoagulant therapy. The levels of von Willebrand factor, PAI-1 and sCD40L were determined by enzyme-linked immunosorbent assay. Statistical data were processed using the Mann–Whitney U-test, the Kruskal-Wallis H-test, quantitative variables were described by the following parameters: median (Me), 25th and 75th percentiles (Q1; Q3). Results: According to obtained data, we can conclude that patients with acute myocardial infarction and concomitant type 2 diabetes mellitus have higher levels of von Willebrand factor, PAI-1 and sCD40L compared to non-diabetic patients with AMI, which leads to the increasing of the platelets adhesion and aggregation and decreasing of fibrinolysis. Conclusions: Urgent restoration of blood supply in occluded artery contributed to a statistically significant reduction in levels of von Willebrand factor, PAI-1 and sCD40L levels in both diabetics and non-diabetic patients, reducing the risk of thromboembolic complications and thus improving the prognosis.