Key result
Pretreatment with ginsenoside Rg5 significantly attenuated renal dysfunction, oxidative stress, and inflammation induced by cisplatin in mice.
Why the study?
Does ginsenoside Rg5 prevent cisplatin-induced nephrotoxicity in mice?
Population
Mouse experimental model of cisplatin-induced nephrotoxicity
Comparison
Ginsenoside Rg5 at doses of 10 and 20 mg/kg for… vs Cisplatin alone
Design
Preclinical
Follow-up
10 days
Authors
Loading...
Hypothesis-generating for ginsenoside Rg5 nephroprotection; prospective human trials needed before any clinical consideration.
Does ginsenoside Rg5 prevent cisplatin-induced nephrotoxicity in mice?
Ginsenoside Rg5 demonstrates nephroprotective effects against cisplatin-induced toxicity in mice through anti-oxidant, anti-inflammatory, and anti-apoptotic mechanisms.
Yan et al. (2016) studied Cisplatin-induced nephrotoxicity. Ginsenoside Rg5 vs. Cisplatin alone was evaluated on Renal dysfunction, oxidative stress, and inflammation response. Pretreatment with ginsenoside Rg5 significantly attenuated renal dysfunction, oxidative stress, and inflammation induced by cisplatin in mice.
Synapse has enriched one closely related paper. Consider it for comparative context: