Key result
High vaccination linked to ~75% lower wastewater PCR detection of rotavirus versus norovirus.
Why the study?
Rotavirus and norovirus are leading causes of acute gastroenteritis with differing environmental and host interactions, and the impact of rotavirus vaccination on viral circulation needed evaluation.
Does wastewater surveillance reflect the impact of rotavirus vaccination on viral circulation?
Observational (n=84)
Does wastewater surveillance reflect the impact of rotavirus vaccination on viral circulation?
Wastewater surveillance of enteric viruses can be a useful tool to measure the impact of specific interventions like rotavirus vaccination.
Answers are grounded in this paper and cite their sources.
May indicate persistent norovirus burden despite rotavirus vaccination; leaves open targeted prevention strategies in developing countries.
Rotavirus and norovirus are the leading causes of acute gastroenteritis worldwide. Both viruses share features such as low infectious dose, high stool concentration and prolonged survival in the environment, including water. However, they differ in several aspects, reflecting potential differences in their interactive capacities with the environment and host. This work, which is a 13-month prospective study in a developing country with high rotavirus vaccine coverage demonstrated a high (44%) PCR detection of norovirus in 84 wastewater samples compared with a relatively low (11%) detection of rotavirus. These results suggest that rotavirus circulation may be positively affected by vaccination and support the use of enteric viral detection in wastewaters as a useful tool to measure the impact of specific interventions.
No takes yet. Share an insight, caveat, or question.
O’Ryan et al. (2012) conducted an observational in Enteric viral circulation (n=84). Rotavirus vaccination vs. Norovirus (unvaccinated reference) was evaluated on PCR detection in wastewater samples. In a highly vaccinated population, PCR detection of rotavirus in wastewater samples was 11%, compared with 44% for norovirus, suggesting vaccination positively affects viral circulation.
Synapse has enriched 10 related papers. Consider them for comparative context: