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January 1, 2015Journal of Investigational Biochemistry

Studies on the Constituents of Rosmarinus officinalis and Their Synergistic Effect in Experimental Diabetic Rats

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Key result

Rosmarinus officinalis extract lowers blood glucose and improves renal and antioxidant markers in diabetic rats.

  • n=24

Why the study?

The antioxidant effects of Rosmarinus officinalis leaf extracts on kidney function in streptozotocin-induced diabetic rats were assessed to explore potential therapeutic benefits.

Does aqueous extract of Rosmarinus officinalis improve antioxidant markers and renal function in STZ-induced diabetic rats?

Comparison

Rosmarinus officinalis extract treatment vs diabetic and non-diabetic controls

Design

Preclinical experimental study

Follow-up

45 days

Authors

MEMohamed El‐BoshyMansoura UniversityEHEslam A. HeaderUmm al-Qura UniversityNENaser A. ElSawyZagazig University

Discussion

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Implication

Antioxidant effects seen in diabetic rat kidneys; leaves open any human translation or clinical relevance.

Structured PICO

Does aqueous extract of Rosmarinus officinalis improve antioxidant markers and renal function in STZ-induced diabetic rats?

P
Population
24 STZ-induced experimental diabetic rats treated with Rosmarinus officinalis extract for 45 days.
I
Intervention
Aqueous extracts of Rosmarinus officinalis (RO) leaves administered orally at a dose of 200 mg/Kg body weight for 45 consecutive days
C
Comparator
Diabetic rats not receiving the extract and non-diabetic control rats
O
Outcome
Blood glucose, antioxidant markers (GSH, SOD, CAT, MDA), and kidney function tests (uric acid, urea, creatinine)surrogate

Aqueous extract of Rosmarinus officinalis significantly improves blood glucose, antioxidant markers, and renal function in a rat model of STZ-induced diabetes.

Cite This Study

El‐Boshy et al. (2015) studied STZ-induced experimental diabetes (n=24). Aqueous extracts of Rosmarinus officinalis (RO) leaves vs. Control rats was evaluated on Blood glucose level, antioxidant markers, and kidney function. Aqueous extracts of Rosmarinus officinalis leaves significantly decreased blood glucose levels and improved antioxidant markers and renal function in STZ-induced diabetic rats.

synapsesocial.com/papers/6ab2039e280f49518bb37964https://doi.org/10.5455/jib.20150519104925
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