A simple and stability indicating HPLC procedure is described for the simultaneous determination of hydrochlorothiazide and propranolol hydrochloride in tablet formulations. Potential degradation products of both drugs and synthesis impurities of hydrochlorothiazide were separated, making the determination stability indicating for both drugs and selective for hydrochlorothiazide. All compounds were chromatographed on a cyanopropylsilane column, eluted with a 15:85 mixture of acetonitrile: 0.05 M ammonium phosphate (pH 3.0) and detected at 290 m. Excellent interlaboratory precision and recovery data were obtained. Linearity studies were carried out using peak area measurements. Detector response to the concentration of each drug was confirmed. The method was applied to dosage forms containing 25 mg of hydrochlorothiazide and 40 or 80 mg of propranolol hydrochloride.
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Hitscherich et al. (1987) studied this question.
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