Aim. To assess the dynamics of cognitive status and oxytocin levels in biological fluids (blood and saliva), as well as their relationship before and after coronary artery bypass surgery. Key points. According to the literature, postoperative cognitive dysfunction occurs in patients after coronary artery bypass grafting. The reasons for its development are factors that influence the preoperative, operational and postoperative stages. Timely diagnosis of cognitive deficit is extremely important, since the more pronounced the cognitive impairment, the less opportunities there are to provide assistance to patients. In this clinical observation, special attention is paid to oxytocin as a biomarker of degenerative brain lesions. Conclusion. We identified the development of postoperative cognitive dysfunction in a patient who did not have such disorders before surgery. There is a direct relationship between the state of cognitive functions and the level of oxytocin in the blood and saliva. Taking into account the data obtained, we propose to consider oxytocin as a biomarker of vascular cognitive disorders.
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Mihailova et al. (2024) studied this question.
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