Answers are grounded in this paper and cite their sources.
Redevelopment of the commercial process for the synthesis of (±)-reboxetine methanesulfonate is described. An optimized and efficient process for the synthesis of (±)-reboxetine starting from cinnamyl alcohol was developed. The redeveloped process minimizes impurity formation and utilizes simplified processing to substantially improve process yield and throughput, and is suitable for the efficient synthesis of multiton quantities of reboxetine.
No takes yet. Share an insight, caveat, or question.
Henegar et al. (2007) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: