Key result
Pathological obesity linked to a ~100% higher rate of newly diagnosed hypertension versus lower BMI.
Why the study?
The frequency of hypertension in patients with pathological obesity was not well characterized using ambulatory blood pressure measurement and in-office BP assessments.
What is the frequency of hypertension and blood pressure profile in patients with pathological obesity compared to overweight and mildly obese patients?
Observational (n=243)
No
What is the frequency of hypertension and blood pressure profile in patients with pathological obesity compared to overweight and mildly obese patients?
Pathological obesity (BMI ≥ 40 kg/m2) is associated with significantly higher blood pressure values and a higher frequency of undiagnosed hypertension, highlighting the importance of ABPM in this population.
Answers are grounded in this paper and cite their sources.
ABPM may aid hypertension detection in obesity; leaves open need for prospective outcome trials before routine adoption.
Obesity and hypertension are one of the most important cardiovascular risk factors. It is predicted that by 2030 almost two-thirds of the global population will struggle with being overweight or obese. Ambulatory Blood Pressure Measurement (ABPM) is a tool for a detailed analysis of mean blood pressure values and assessing the blood pressure profile during the night with the daily values and optimal treatment determination. The study aimed to assess the frequency of hypertension in patients with pathological obesity. The study consisted of two groups depending on their Body Mass Index (BMI): Group 1 BMI > 25 kg/m2; < 40 kg/m2; Group 2 (243 overweight and obese patients): BMI ≥ 40 kg/m2. Each patient was carefully interviewed, considering their use of the antihypertensive drugs. Each patient was subject to the ABPM assessment. Arterial hypertension (HT) was diagnosed at arterial blood pressure (BP) values > 135/85 mmHg based on the European Society of Hypertension (ESH) test bench. Depending on the patient’s history, ABPM, and in-office BP measurements, patients were diagnosed with HT treated, newly diagnosed, or without HT. Based on the in-office BP and ABPM measurements taken, the diagnosis of white-coat uncontrolled hypertension (WUCH) and masked uncontrolled hypertension (MUCH) was diagnosed. The analysis of parameters revealed that all BP values were significantly higher in group 2. More than half of the patients in both groups had been previously treated for HT. Based on ABPM, newly diagnosed HT was identified significantly more often in patients with higher BMI. The younger individuals were significantly more likely to have WUCH.
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Moczulska et al. (2023) conducted an observational in Obesity (n=243). Pathological obesity (BMI ≥ 40 kg/m2) vs. Overweight and obesity class I-II (BMI 25 to < 40 kg/m2) was evaluated on Newly diagnosed hypertension based on ABPM (p=0.046). Pathological obesity (BMI ≥ 40 kg/m2) was associated with a higher frequency of newly diagnosed hypertension compared to lower BMI categories.
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