Answers are grounded in this paper and cite their sources.
A practical, efficient synthesis of 1, a hepatitis C virus RNA replication inhibitor, is described. Starting with the inexpensive diacetone glucose, the 12-step synthesis features a novel stereoselective rearrangement to prepare the key crystalline furanose diol intermediate. This is followed by a highly selective glycosidation to couple the C-2 branched furanose epoxide with deazapurine.
No takes yet. Share an insight, caveat, or question.
Bio et al. (2004) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: