Key result
A higher oxidative balance score (highest vs lowest tertile) was associated with reduced incident CKD risk in women (HR 0.76; 95% CI 0.59-0.98) and men (HR 0.80; 95% CI 0.59-1.08).
Why the study?
Does a higher Oxidative Balance Score (OBS) reduce the incidence of chronic kidney disease in adults without baseline CKD?
Cohort (n=5,795)
Does a higher Oxidative Balance Score (OBS) reduce the incidence of chronic kidney disease in adults without baseline CKD?
Hazard Ratio: 0.76 (95% CI 0.59–0.98)
A higher oxidative balance score, reflecting a diet and lifestyle rich in antioxidants, is associated with a reduced risk of incident chronic kidney disease over a 13.6-year follow-up.
Higher OBS may link to lower CKD risk in women; hypothesis-generating and requires prospective trials before practice change.
Oxidative stress is a novel risk factor for chronic kidney disease (CKD). The oxidative balance score (OBS) was developed to represent the overall oxidative balance based on dietary and lifestyle pro-oxidant and antioxidant components. The aim of this study is to verify the relationship between the OBS and the incidence of CKD. Data from 5795 participants without CKD at the baseline survey of the Korean Genome and Epidemiology Study were analyzed. Participants were classified into sex-specific OBS tertiles. During the mean follow-up period of 13.6 years, 286 men and 382 women newly developed CKD. The Cox proportional hazard spline curve revealed an inverse dose-response association between the OBS and incident CKD in both men and women. Multiple Cox proportional hazard regression analysis revealed that the adjusted hazard ratios (95% confidence intervals) for sex-specific highest (T3) and middle (T2) OBS tertile groups were 0.80 (0.59-1.08) and 0.70 (0.51-0.95), respectively, in men and 0.76 (0.59-0.98) and 0.73 (0.55-0.96), respectively, in women, with the sex-specific lowest OBS tertile group (T1) as the reference. These results suggest that a healthy diet and lifestyle that increases the OBS may help prevent CKD in both men and women.
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Son et al. (2023) conducted a cohort in Chronic Kidney Disease (n=5,795). Oxidative balance score (OBS) vs. Lowest OBS tertile (T1) was evaluated on Incident chronic kidney disease (HR 0.76, 95% CI 0.59-0.98). A higher oxidative balance score (highest vs lowest tertile) was associated with reduced incident CKD risk in women (HR 0.76; 95% CI 0.59-0.98) and men (HR 0.80; 95% CI 0.59-1.08).
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