Key result
Higher pericardial and epicardial fat volumes strongly correlate with greater coronary artery stenosis severity.
Why the study?
Epicardial fat volume and pericardial fat volume have been reported to correlate with coronary artery disease severity, but their relationship with coronary artery stenosis severity requires further investigation.
Do epicardial and pericardial fat volumes correlate with the severity of coronary artery stenosis in patients undergoing MSCT for suspected CAD?
Cross-Sectional (n=151)
Investigators blinded to EFV and clinical characteristics
No
Do epicardial and pericardial fat volumes correlate with the severity of coronary artery stenosis in patients undergoing MSCT for suspected CAD?
Effect estimate: r=0.75 for PFV, r=0.79 for EFV
p-value: p=<0.001
Epicardial and pericardial fat volumes measured by MSCT strongly correlate with the severity of coronary artery stenosis, suggesting their utility as markers for CAD severity.
May support fat volumes as adjunct CAD markers on MSCT; leaves open incremental prognostic value in prospective studies.
INTRODUCTION: Epicardial fat volume (EFV) has been reported to correlate with the severity of coronary artery disease (CAD). Pericardial fat volume (PFV) has recently been reported to be strongly associated with CAD severity and presence. We aimed to investigate the relationship between EFV and PFV with severity of coronary artery stenosis in patients undergoing 64-slice multi-slice computed tomography (MSCT). METHODS: One hundred and fifty one patients undergoing MSCT for suspected CAD were enrolled. Non-enhanced images were acquired to assess calcium score. Contrast enhanced images were used to quantify EFV, PFV and severity of luminal stenosis. RESULTS: Coronary artery stenosis was mild in 25 cases (16.6%), moderate in 58 cases (38.4%) and severe in 68 cases (45%). With increase in severity of coronary artery stenosis, there was significant increase in PFV, EFV as well as epicardial fat thickness in right ventricle free wall in basal view and epicardial fat thickness in left ventricle posterior wall in mid and apical view. There was significant linear correlation between PFV with coronary calcification score (r=0.18, P=0.02), between coronary artery stenosis severity and PFV (r=0.75, P<0.001), EFV (r=0.79, P<0.001), apical epicardial fat thickness in right ventricle free wall (r=0.29, P<0.001), Mid (r=0.28, P<0.001) and basal (r=0.23, P=0.004) epicardial fat thickness in left ventricle posterior wall. CONCLUSION: PFV, EFV and regional epicardial thickness are correlated with severity of CAD and could be used as a reliable marker in predicting CAD severity.
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Aslanabadi et al. (2014) conducted a cross-sectional in Suspected Coronary Artery Disease (n=151). Epicardial and Pericardial Fat Volume was evaluated on Correlation between pericardial fat volume (PFV) and epicardial fat volume (EFV) with coronary artery stenosis severity (r=0.75 for PFV, r=0.79 for EFV, p=<0.001). Pericardial and epicardial fat volumes were significantly correlated with the severity of coronary artery stenosis (r=0.75 and r=0.79, respectively, P<0.001).
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