Key result
AMI-related mortality among U.S. cancer patients drops ~67% between 1999 and 2020.
Why the study?
Mortality trends for acute myocardial infarction-related deaths in adult cancer patients in the U.S. remain unexplored.
Observational (n=109,462)
Yes
Effect estimate: APC 6.65 (95% CI 6.95 to -6.40)
Absolute Event Rate: 1.4% vs 4.3%
p-value: p=<0.001
AMI-related mortality among U.S. cancer patients declined significantly from 1999 to 2015 but plateaued thereafter, with persistent disparities by gender, age, race, and geography.
Declining then plateaued AMI mortality in cancer patients shows persistent disparities; leaves open drivers and equity-focused interventions.
Background: Cancer patients are at an increased risk for the incidence and complications of acute myocardial infarction (AMI) due to shared risk factors and treatment-related adverse effects. Mortality trends for AMI-related deaths in adult cancer patients in the U.S. remain unexplored. Methodology: This study used CDC WONDER data for death certificates from 1999 to 2020, identifying U.S. adults (≥25 years) with cancer (ICD-10: C00-D49) who died of AMI (ICD-10: I21) as the underlying cause. Age-adjusted mortality rates (AAMRs) and annual percent changes (APCs) were calculated and stratified by gender, age, race, and geographic location. Results: Between 1999 and 2020, there were 109,462 AMI-related deaths in adult cancer patients. The AAMR decreased from 4.3 per 100,000 in 1999 to 1.4 in 2020. A significant decline occurred from 1999 to 2015 (APC: 6.65; 95 % CI: 6.95 to -6.40; p < 0.001), followed by a stable trend from 2015 to 2020 (APC: 1.36; 95 % CI: 2.69 to 0.91; p = 0.152). Men had higher AAMRs than women (3.5 vs. 1.5). AAMRs were highest in older adults (10.5) compared to middle-aged (0.7) and young adults (0.1). Racial disparities showed the highest AAMRs in non-Hispanic (NH) Black patients (2.7), followed by NH Whites (2.4), NH American Indian/Alaska Native (1.6), Hispanic/Latino (1.3), and NH Asian/Pacific Islander (1.1). Non-metropolitan areas had higher AAMRs than metropolitan areas (2.8 vs. 2.2). Conclusions: This analysis highlights a significant decline in AMI-related mortality among cancer patients in the U.S., with persistent disparities by gender, age, race and geographical location.
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Saeed et al. (2025) conducted an observational in Cancer and acute myocardial infarction (n=109,462). Time period (1999-2020) vs. 1999 (baseline) was evaluated on Age-adjusted mortality rate (AAMR) for AMI-related deaths per 100,000 (APC 6.65, 95% CI 6.95 to -6.40, p=<0.001). Between 1999 and 2020, the age-adjusted mortality rate for AMI-related deaths among U.S. adult cancer patients decreased significantly from 4.3 to 1.4 per 100,000.
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