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Why Rodent Lethality Models Are Problematic for Evaluating Antivenoms for Human Envenoming?The majority of snake venoms that cause paralysis in envenomed humans contain pre-synaptic neurotoxins, which cause paralysis that is, not reversible with antivenom (Silva et al., 2017(Silva et al., , 2018)).The other major group of snake neurotoxins are the post-synaptically acting α-neurotoxins.These toxins are present in venoms from a range of snakes, including many species that do not result in
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Silva et al. (2022) studied this question.
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