Key result
Metabolic syndrome is linked to a ~2-fold increase in incident stroke risk.
Why the study?
The association between Metabolic Syndrome and risk of stroke in the population of Novosibirsk aged 45–69 years was not well characterized.
Does Metabolic Syndrome increase the risk of stroke in residents of Novosibirsk aged 45-69 years?
Cohort (n=9,363)
Yes
Does Metabolic Syndrome increase the risk of stroke in residents of Novosibirsk aged 45-69 years?
Metabolic syndrome, particularly the combination of hypertension and abdominal obesity, significantly increases the risk of stroke in an urban Siberian population.
Answers are grounded in this paper and cite their sources.
May support intensified stroke surveillance in metabolic syndrome; leaves open whether modification improves outcomes.
Aim.To explore the association between Metabolic Syndrome (MS) and risk of stroke in Novosibirsk citizens aged 45–69 years. Material and methods.As a part of an international prospective cohort HAPIEE study the population sample of 9363 residents of Novosibirsk aged 45–69 years were surveyed by screening method. Results.A high prevalence of metabolic disorders in the population was revealed; the levels and distribution of cardiometabolic factors in first-ever stroke examined. It was found by the “case-control” study, that the combination of hypertension and abdominal obesity (AO) increases the odds ratio (OR) for stroke in the population studied. Conclusion.It was shown to 2-fold increase in the risk of stroke in people with MS by 9-year prospective observation. Prognostic models of combining components of MS affecting the OR of stroke were identified in an urban population of Siberia.
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Шишкин et al. (2014) conducted a cohort in Metabolic Syndrome and Stroke (n=9,363). Metabolic Syndrome vs. Absence of Metabolic Syndrome was evaluated on Stroke (2-fold increase). Metabolic syndrome was associated with a 2-fold increase in the risk of stroke over a 9-year prospective observation period.
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