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Intestinal fibrosis is the intestinal tissue's response to the injury caused by recurrent chronic inflammation.It is a common and serious complication of inflammatory bowel disease, characterized by excessive proliferation and accumulation of extracellular matrix in the intestine.The mechanism of its formation may be related to the excessive proliferation of intestinal stromal cells, extracellular stroma, epithelial-mesenchymal transformation and the interaction of various cytokines.Here we review the mechanism of intestinal fibrosis and try to find the implication for potential therapeutic strategies.
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Cheng Lan (2022) studied this question.
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