Key result
Ovarian PPARgamma expression differs between adult and immature rats while PPARalpha drops during estrus.
Why the study?
The expression patterns of mRNAs for PPAR family members in ovarian luteal tissue during pseudopregnancy and the estrous cycle were not well characterized.
Population
Ovaries from gonadotropin-treated immature rats and adult cycling rats
Comparison
Pseudopregnant rats vs naturally cycling rats
Design
In situ hybridization and RNase protection assay study
Authors
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PPAR isoform expression during rat CL development supports a regulatory role in luteal remodeling; leaves open functional relevance in humans.
p-value: p=<0.05
Komar et al. (2002) studied this question. Pseudopregnancy and gonadotropin treatment vs. Adult cycling rats was evaluated on Expression of mRNA corresponding to the PPAR family members (alpha, delta, and gamma) in luteal tissue (p=<0.05). Ovarian expression of PPARgamma mRNA differed between adult cycling rats and immature gonadotropin-treated rats, while PPARalpha mRNA levels were lower on the day of estrus (P<0.05).
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