What question did this study set out to answer?

To describe the clinical presentation, diagnostic imaging, and postmortem pathological and immunohistochemical characteristics of metastatic intrahepatic cholangiocarcinoma in a captive puma (Puma concolor).

June 19, 2025AnimalsOpen Access

Diagnostic Approach and Pathological Characterization of Metastatic Intrahepatic Cholangiocarcinoma in a Captive Puma (Puma concolor)

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Authors

EMElisa MazzottaIstituto Zooprofilattico Sperimentale delle Venezie CZClaudia ZanardelloIstituto Zooprofilattico Sperimentale delle Venezie GZGiovanni De ZottisIstituto Zooprofilattico Sperimentale delle Venezie

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Implication

Case report demonstrates metastatic intrahepatic cholangiocarcinoma in a captive puma, highlighting immunohistochemical markers for identifying rare felid biliary tumors.

Key Points

To describe the clinical presentation, diagnostic imaging, and postmortem pathological and immunohistochemical characteristics of metastatic intrahepatic cholangiocarcinoma in a captive puma (Puma concolor).
Clinical and diagnostic imaging evaluation of a single captive puma presenting with progressive weight loss and gastrointestinal signs.
Postmortem gross necropsy followed by histopathologic evaluation and immunohistochemical staining for pan-cytokeratins, CK7, and CK20.
Gross necropsy identified marked cavitary effusions, multiple left hepatic lobe masses, and widespread metastases in the peritoneum, pericardium, kidney, spleen, and spermatic cord.
Histopathology confirmed tubular and acinar structures within a desmoplastic stroma, with neoplastic cells showing strong immunoreactivity for pan-cytokeratins and CK7, and weaker positivity for CK20.

Cite This Study

Mazzotta et al. (2025) studied this question.

synapsesocial.com/papers/6ab2204269afa1f6b5d77832 https://doi.org/10.3390/ani15121821

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Implication

Case report demonstrates metastatic intrahepatic cholangiocarcinoma in a captive puma, highlighting immunohistochemical markers for identifying rare felid biliary tumors.

Diagnostic Approach and Pathological Characterization of Metastatic Intrahepatic Cholangiocarcinoma in a Captive Puma (Puma concolor)

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Key Points

Cite This Study

Diagnostic Approach and Pathological Characterization of Metastatic Intrahepatic Cholangiocarcinoma in a Captive Puma (Puma concolor)

Discussion

Member takes

Implication

Key Points

Cite This Study

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