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March 24, 2019Journal of Investigative SurgeryOpen Access

Apoptosis and Autophagy in the Pathogenesis of Osteoarthritis

Paola Castrogiovanni Silvia Ravalli Giuseppe Musumeci

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Abstract

Osteoarthritis (OA) is a degenerative disease in which a low-grade inflammation in cartilage and synovium occurs, causing a deterioration of cartilage and the consequent joint disability. OA is a m...

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Castrogiovanni et al. (2019) studied this question.

synapsesocial.com/papers/6ab221434e93f6b53d7dc563 https://doi.org/10.1080/08941939.2019.1576811

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Expression of β‐defensin‐4 in “an in vivo and ex vivo model” of human osteoarthritic knee meniscusOriginal Research · 2011 · 47 citations
2Characterization of apoptosis in articular cartilage derived from the knee joints of patients with osteoarthritisOriginal Research · 2010 · 113 citations
3Chondrocyte apoptosis: a cause or consequence of osteoarthritis?Original Research · 2011 · 177 citations
4Nitric oxide from both exogenous and endogenous sources activates mitochondria‐dependent events and induces insults to human chondrocytesOriginal Research · 2007 · 109 citations
5p38 Kinase Regulates Nitric Oxide-induced Apoptosis of Articular Chondrocytes by Accumulating p53 via NFκB-dependent Transcription and Stabilization by Serine 15 PhosphorylationOriginal Research · 2002 · 168 citations

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Biomarkers of Chondrocyte Apoptosis and Autophagy in Osteoarthritis2015
Rapamycin Inhibits Nf-ΚB Activation by Autophagy to Reduce Catabolism in Human Chondrocytes2019
Local intra-articular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis2014

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