Optimization of Treatment of Patients With Non-Ischemic Central Retinal Vein Occlusion

An urgent issue in modern ophthalmology is the search for pathogenetic markers of retinal vascular diseases, the development of criteria for predicting and personalizing treatment. The present study of 32 patients with a non-ischemic type of central retinal vein occlusion showed that in the early period (up to 7 days after the onset of the disease), the content of VEGF-A in the lacrimal fluid and MCP-1 in the lacrimal fluid significantly increased, the best-corrected visual acuity decreased (BCVA), and the thickness of the retina in the fovea centralis increased. Based on the obtained clinical and laboratory data, a model based on logistic regression was developed, which included the studied indicator of the content of the most significant biomarker VEGF-A in lacrimal fluid and the morphofunctional state of the macular zone of the retina - the value of BCVA and the result of the instrumental examination method (optical coherence tomography) - the thickness of the retina in fovea centralis. The resulting model has a higher statistically significant difference reliability and higher accuracy and specificity, which allows it to be used to personalize the treatment algorithm and predict the outcome of the disease. Based on the model, a patient treatment algorithm has been developed that optimizes the management of patients with non-ischemic central retinal vein occlusion.