Revealing of Anti-inflammatory Agent from Garcinia mangostana L. Phytochemical as NF-κB Inhibitor Mechanism through In Silico Study

Immune response that occurs when a pathogen such as a virus, fungus, bacteria, & protozoa. Red color due to swelling is a characteristic of inflammation, this condition can occur due to high blood flow and increased membrane permeability in the area of ​​infection, inflammation is also caused by tumors, cancer, and autoimmune diseases by infectious microorganisms. NF-κB regulation has also been identified to be associated with conditions for the transformation of normal cells into cancer, specific autoimmune diseases, and viral infections. Previous studies have shown the potential of Gracinia mangostana L. for anti-inflammatory, but the molecular mechanism of anti-inflammatory in these two compounds has not been found. This research was conducted to reveal the potential of compounds from Garcini mangostana L. as anti-inflammatory agents through an in silico approach. Gamma-mangostin from Garcinia mangostana L. are predicted to be anti-inflammatory agents, this compound can produce more negative binding affinity and weak bond interactions. This indicates the stability of the binding interaction that triggers the inhibitory activity.