Key result
Carotid plaque burden outperforms IMT for risk stratification and monitoring atherosclerosis therapies.
Why the study?
Measurement of carotid plaque burden is increasingly recognized as superior to carotid intima-media thickness for risk stratification and assessing atherosclerosis, but its uses and advantages need clarification.
Is measurement of carotid plaque burden superior to carotid intima-media thickness for assessing atherosclerosis?
Is measurement of carotid plaque burden superior to carotid intima-media thickness for assessing atherosclerosis?
Answers are grounded in this paper and cite their sources.
Measurement of carotid plaque burden (TPA, TPV, VWV) is superior to carotid intima-media thickness (IMT) for risk stratification and monitoring atherosclerosis therapies.
Purpose of review To describe the uses of measurement of carotid plaque burden, as total plaque area (TPA), total plaque volume (TPV), and vessel wall volume (VWV), which includes plaque burden and wall volume. Recent findings Measurement of plaque burden is useful for risk stratification, research into the genetics and biology of atherosclerosis, for measuring effects of new therapies for atherosclerosis, and for treatment of high-risk patients with severe atherosclerosis. Summary Measurement of plaque burden is far superior to measurement of carotid intima-media thickness (IMT) in many ways, and should replace it. Vessel wall volume can be measured in persons with no plaque as an alternative to IMT.
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J. David Spence (2015) conducted a review in Atherosclerosis. Measurement of carotid plaque burden vs. Carotid intima-media thickness (IMT) was evaluated. Measurement of carotid plaque burden is superior to carotid intima-media thickness for risk stratification and assessing atherosclerosis therapies.
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