Key result
BP <140/90 linked to higher 6-month major event risk versus 140-159/90-99 after acute ischemic stroke.
Why the study?
The optimal blood pressure levels and the relative importance of blood pressure and blood pressure variability in the early phase of acute ischemic stroke with hypertension and carotid artery stenosis were unclear.
Does maintaining specific blood pressure levels and low blood pressure variability improve outcomes in the early phase of acute ischemic stroke with hypertension and carotid stenosis?
Cohort (n=750)
No
Does maintaining specific blood pressure levels and low blood pressure variability improve outcomes in the early phase of acute ischemic stroke with hypertension and carotid stenosis?
In the early phase of acute ischemic stroke with hypertension and carotid stenosis, strict blood pressure control (<140/90 mm Hg) may be harmful, whereas maintaining low blood pressure variability improves prognosis.
No takes yet. Share an insight, caveat, or question.
May caution against strict BP targets in acute ischemic stroke; leaves open variability effects in prospective trials.
He et al. (2021) conducted a cohort in Acute ischemic stroke with hypertension and carotid artery stenosis (n=750). Low blood pressure levels (SBP < 140 and DBP < 90 mm Hg) and blood pressure variability vs. Moderate blood pressure levels (SBP 140-159 and/or DBP 90-99 mm Hg) was evaluated on Recurrent stroke, all-cause death and composite cardiovascular events at 6 months. Low blood pressure (<140/90 mm Hg) was associated with more recurrent stroke, death, and cardiovascular events at 6 months compared to 140-159/90-99 mm Hg in acute ischemic stroke patients.
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