What question did this study set out to answer?

To evaluate circulating interleukin-6 (IL-6) levels in complicated COVID-19 and examine preliminary clinical evidence regarding the anti-IL-6 biologic tocilizumab.

April 3, 2020Open Access

Interleukin-6 in COVID-19: A Systematic Review and Meta-Analysis

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Authors

ECEric A. CoomesUniversity of Toronto HHHourmazd HaghbayanUniversity Health Network

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Implication

Systematic review and meta-analysis finds elevated interleukin-6 in complicated COVID-19, suggesting targeted inhibition with tocilizumab may improve patient outcomes.

Key Points

To evaluate circulating interleukin-6 (IL-6) levels in complicated COVID-19 and examine preliminary clinical evidence regarding the anti-IL-6 biologic tocilizumab.
Systematic search of MEDLINE, EMBASE, and grey literature for studies evaluating immunological responses or tocilizumab treatment in COVID-19 (PROSPERO CRD42020175879).
Synthesis of eligible published studies, pre-prints, and registered trials using random-effects meta-analytic models.
Meta-analysis revealed 2.9-fold higher mean IL-6 concentrations in patients with complicated COVID-19 compared to non-complicated cases (6 studies; n=1302; 95% CI, 1.17–7.19; I²=100%).
A single non-randomized, single-arm study in severe COVID-19 demonstrated reduced oxygen requirements, radiographic clearing, and clinical improvement following tocilizumab administration, with no reported deaths or adverse events.

Cite This Study

Coomes et al. (2020) studied this question.

synapsesocial.com/papers/6ab23361fd33d6c8efe8edad https://doi.org/10.1101/2020.03.30.20048058

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Implication

Systematic review and meta-analysis finds elevated interleukin-6 in complicated COVID-19, suggesting targeted inhibition with tocilizumab may improve patient outcomes.

Interleukin-6 in COVID-19: A Systematic Review and Meta-Analysis

Discussion

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Implication

Key Points

Cite This Study

Interleukin-6 in COVID-19: A Systematic Review and Meta-Analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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