Image-based modeling: A novel tool for realistic simulations of artificial bone cultures

Computational modeling has been promulgated as a means of optimizing artificial bone tissue culturing ex vivo. In the present report, we show, as a proof-of-concept, that it is possible to model the exact microenvironment within the scaffolds while accounting for their architectural complexities and the presence of cells/tissues in their pores. Our results clearly indicate that image-based modeling has the potential to be a powerful tool for computer-assisted tissue engineering.