Key result
Novel clinical nomogram predicts postoperative cognitive dysfunction after cardiac surgery with ~0.82 AUC.
Why the study?
Cardiac postoperative cognitive dysfunction (c-POCD) is a common complication and a predictive tool to identify high-risk patients is needed for early prevention.
Can a nomogram incorporating preoperative and intraoperative variables predict cardiac postoperative cognitive dysfunction in patients undergoing cardiac surgery?
Observational (n=265)
Can a nomogram incorporating preoperative and intraoperative variables predict cardiac postoperative cognitive dysfunction in patients undergoing cardiac surgery?
Odds Ratio: 6.696 (95% CI 2.068–21.675)
p-value: p=0.0015
A novel nomogram incorporating five clinical variables shows good predictive accuracy for identifying patients at high risk of early postoperative cognitive dysfunction after cardiac surgery.
Nomogram may aid preoperative c-POCD risk stratification; leaves open prospective validation before clinical adoption.
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Xie et al. (2021) conducted an observational in Cardiac postoperative cognitive dysfunction (n=265). Prolonged CPB time, hypertension, elevated WBC count, elevated AST, and arrhythmia vs. Absence of these risk factors was evaluated on Cardiac postoperative cognitive dysfunction (c-POCD) (OR 6.696, 95% CI 2.068-21.675, p=0.0015). A nomogram incorporating CPB time, hypertension, WBC count, AST, and arrhythmia predicted cardiac postoperative cognitive dysfunction with an AUC of 0.8188 (95% CI 0.7185-0.9190).
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