What question did this study set out to answer?

To investigate the effect of levothyroxine replacement therapy on renal function markers in hypothyroid patients before and after achieving euthyroidism.

March 13, 2017Endocrine Research

Renal function improves with the treatment of hypothyroidism

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Authors

OBOktay BulurIstanbul Medipol University KDKürşat DalAnkara University DEDerun Taner ErtuğrulVan Yüzüncü Yıl Üniversitesi

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Implication

Retrospective study reveals improved renal function following levothyroxine replacement in hypothyroid patients, indicating that thyroid hormone deficiency causes reversible kidney impairment.

Key Points

To investigate the effect of levothyroxine replacement therapy on renal function markers in hypothyroid patients before and after achieving euthyroidism.
Conducted a retrospective cohort evaluation of patients assessed during both hypothyroid and euthyroid states.
Measured serum levels of free T3 (fT3), free T4 (fT4), thyroid-stimulating hormone (TSH), and creatinine.
Calculated estimated glomerular filtration rate (eGFR) using the simplified Modification of Diet in Renal Disease formula.
Achieving euthyroidism with levothyroxine significantly increased fT3, fT4, and eGFR measurements, while significantly decreasing serum creatinine and TSH levels (p < 0.0001 for all).
Changes in TSH correlated positively with changes in creatinine (r = 0.288, p < 0.0001) and negatively with changes in eGFR (r = -0.272, p < 0.0001).
Abnormally elevated creatinine levels completely returned to normal ranges in a subset of patients once euthyroid status was achieved.

Cite This Study

Bulur et al. (2017) studied this question.

synapsesocial.com/papers/6ab2369de8d68c1c7b07db0e https://doi.org/10.1080/07435800.2017.1293686

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Implication

Retrospective study reveals improved renal function following levothyroxine replacement in hypothyroid patients, indicating that thyroid hormone deficiency causes reversible kidney impairment.

Renal function improves with the treatment of hypothyroidism

Discussion

Member takes

Implication

Key Points

Cite This Study

Renal function improves with the treatment of hypothyroidism

Discussion

Member takes

Implication

Key Points

Cite This Study

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