Key result
Mesalazine is linked to severe multi-organ adverse effects including pericarditis and pericardial effusion.
Why the study?
Adverse reactions including fever, vasculitic rash, arthritis, pericarditis, and pericardial effusion after mesalazine treatment in ulcerative colitis are not well characterized.
Does mesalazine cause fever, vasculitic rash, arthritis, pericarditis, and pericardial effusion in a patient with ulcerative colitis?
Case Report (n=1)
Does mesalazine cause fever, vasculitic rash, arthritis, pericarditis, and pericardial effusion in a patient with ulcerative colitis?
Mesalazine can induce severe adverse reactions including pericarditis and pericardial effusion in patients with ulcerative colitis.
Mesalazine may rarely trigger pericarditis and systemic symptoms in UC; single case leaves open causality and incidence.
A 30 year old man with an 11 year history of mild ulcerative colitis presented with a relapse. He had been treated with oral sulphasalazine in the past with no ill effect, but during a recent relapse he developed a vasculitic rash on his lower legs and painful swollen ankles after three weeks of sulphasalazine treatment. These symptoms had receded a couple of days after stopping sulphasalazine. We therefore gave him oral mesalazine (800 mg a day), rectal hydrocortisone (25 mg a …
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Lin et al. (1994) conducted a case report in Ulcerative colitis (n=1). Mesalazine was evaluated on Adverse reactions (Fever, vasculitic rash, arthritis, pericarditis, and pericardial effusion). Oral mesalazine administration in a 30-year-old man with ulcerative colitis was associated with the development of fever, vasculitic rash, arthritis, pericarditis, and pericardial effusion.
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