Key result
Lower adiponectin linked to more severe NAFLD, falling ~57% from Grade I to III.
Why the study?
Adiponectin is thought to play a role in insulin resistance and is associated with NAFLD incidence, but its relationship with NAFLD degree is unclear.
Cross-Sectional (n=67)
No
p-value: p=<0.001
Lower adiponectin levels are significantly associated with higher degrees of NAFLD and fibrosis in patients with metabolic syndrome.
Hypothesis-generating for adiponectin as NAFLD severity marker in metabolic syndrome; prospective studies needed before clinical use.
Background: NAFLD is liver fat that exceeds 5% of the total liver weight. Adiponectin is thought to have a role in the development of insulin resistance and is associated with the incidence of NAFLD. This study aims to find the relationship between adiponectin levels and the degree of NAFLD. Methods: Sixty seven study subjects with metabolic syndrome, went through abdominal ultrasound to diagnose NAFLD and measure BMI, serum adiponectin levels, and NAFLD Fibrosis Score (NFS). The relationship between adiponectin levels, degrees of NAFLD, NFS, and comorbid would be assessed. Results: Forty one (61%) was male and 26 (38.8%) were female with a mean age of 42.08 years. From the abdominal ultrasound, the number of NAFLD grade I, II, and III were 40.4%, 29.8%, 29.8%. The mean adiponectin levels in all samples were 7.13 (3.25-11.45) μg/ml. Both type 2 diabetes and BMI ≥ 23 kg/m2 were associated with the degree of NAFLD (p <0.001). In type 2 diabetes and BMI ≥ 23 kg/m2 group, the mean adiponectin level was found to be lower (p <0.001). The relationship between NFS and NAFLD, also adiponectin levels and the degree of NFS was significant (p <0.001). Conclusion: The relationship between adiponectin levels with the degree of NAFLD and NFS were statistically significant.
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Andriani et al. (2021) conducted a cross-sectional in Non-Alcoholic Fatty Liver Disease (NAFLD) (n=67). Serum adiponectin levels was evaluated on Mean serum adiponectin levels by NAFLD grade (p=<0.001). Lower serum adiponectin levels were significantly associated with more severe degrees of NAFLD, decreasing from 9.59 μg/ml in Grade I to 4.12 μg/ml in Grade III (p < 0.001).
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